3-dimensional multi-modality non-invasive imaging of the bone marrow engraftment model

Failure Marrow Transplantation after Engraftment Promotes Engraftment for Secondary Bone Primary Bone Marrow Transplantation

The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

Purification of rare hematopoietic stem cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts represent the gold standard for demonstrating self-renewal and differentiation, the defining properties of HSC. We show that rare cells that home to bon...

Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches.

Xenotransplantation of patient-derived samples in mouse models has been instrumental in depicting the role of hematopoietic stem and progenitor cells in the establishment as well as progression of hematological malignancies. The foundations for this field of research have been based on the development of immunodeficient mouse models, which provide normal and malignant human hematopoietic cells ...

Multi-modality imaging of pheochromocytoma

Pheochromocytoma, a rare neuroendocrine adrenal tumor, is often diagnosed by a combination of clinical, laboratory, and radiographic features. While the imaging features of this entity are variable, the use of complementary modalities often helps to target the diagnosis and assess the extent of the disease. We present a multi-modality evaluation of a pheochromocytoma, with CT, MR, MIBG, and pat...